Comparison of serum 25-(OH)D levels between the BPD and non-BPD groups. (A) Serum 25-(OH)D level at birth; (B) serum 25-(OH)D level at 6 months after 40 weeks of corrected gestational age. ****, P<0.0001. BPD, bronchopulmonary dysplasia.
On pulmonary function tests, we found that long-term infants in the BPD group had significantly increased RR and considerably lower VT, TI/TE, TPEF/TE, and TEF 25% compared to those in the non-BPD group, and the differences were statistically significant (P<0.05). There were no notable differences between the two groups in terms of VPEF/VE, TEF 50%, and TEF 75%. The proportion of children with lung function impairment in the BPD group was 79.7% (), which was significantly higher than the proportion of children with lung function impairment in the non-BPD group (29.9%, ). The difference was statistically significant (P<0.05) ( Table 4 ).
Logistic regression analysis of risk factors to your development of BPD into the preterm kids
Univariate regression analysis was first performed to determine whether BPD occurred as a dependent variable in logistic regression analysis. Independent variable indicators with statistical significance (P<0.05) in the analysis results were included in the multivariate analysis. Finally, the length of hospital stay, total oxygen therapy duration, neonatal pneumonia, neonatal asphyxia, and serum 25-(OH)D level at birth were identified as independent variables in the multivariate logistic regression analysis. The results showed that total oxygen therapy duration, neonatal pneumonia, neonatal asphyxia, and serum 25-(OH)D levels at birth were independent risk factors for the development of BPD in preterm infants (P<0.05, Table 5 ).
Though BPD is one of the most well-known severe complications during the preterm babies, the right pathogenesis remains unclear at this time. Students with BPD is introduce medically which have progressive dyspnea, hypoxemia, etcetera. Really serious times can develop issue such as for instance pulmonary blood pressure level and even pulmonary cardiovascular disease, mainly as a result of the pathophysiological changes secondary toward big lung injury of your inspired pupils, together with diminished pulmonary conformity and you can improved airway resistance dysregulated ventilation/flow proportion. Youngsters that have BPD provides a bad enough time-term analysis. He could be prone to perennial respiratory attacks, wheezing, cardiopulmonary disability, and you will backwards real creativity, seriously impacting the quality of life.